Download E-books Absorption and Drug Development: Solubility, Permeability, and Charge State PDF

By Alex Avdeef

Explains the way to practice and learn the result of the newest physicochemical methods

With this publication as their advisor, readers have entry to the entire present details had to completely examine and appropriately make certain a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining all of the physicochemical equipment used at the present time to research drug applicants. additionally, the writer offers professional counsel to assist readers research the result of their reports with a view to decide on the main promising drug candidates.

This Second Edition has been completely up-to-date and revised, incorporating all of the most recent learn findings, equipment, and assets, including:

• Descriptions and purposes of latest PAMPA types, drawing on greater than thirty papers released by means of the author's study group

• Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier

• Expanded info and strategies to aid pKa determination

• New examples explaining the therapy of essentially insoluble try out compounds

• Additional case reports demonstrating using the most recent physicochemical techniques

• New, revised, and elevated database tables in the course of the book

Well over two hundred drawings aid readers greater comprehend tricky options and supply a visible advisor to complicated methods. additionally, over 800 references function a gateway to the first literature within the box, facilitating extra examine into all of the subject matters coated within the book.

This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar parts of study. it's also instructed as a supplemental textual content for graduate classes in pharmaceutics.