By Han van de Waterbeemd, Bernard Testa, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
The most beneficial for business study now thoroughly revised according to present traits within the box, with all contributions commonly up to date or rewritten. In 21 chapters readers can enjoy the key operating wisdom of latest major pharmaceutical businesses, together with Pfizer, AstraZeneca, and Roche. Drug builders from and academia current the entire components governing drug bioavailability, whole with sensible examples and real-life information. half I specializes in in vitro and in vivo measurements of physicochemical homes, comparable to membrane permeability and ionization. half II discusses solubility and gastrointestinal absorption, whereas the 3rd half is dedicated to metabolism and excretory mechanisms. The a lot revised and improved half IV surveys present in silico ways to foretell drug homes had to estimate the bioavailability of any new drug candidate. the ultimate half indicates how bad bioavailability might be stronger by means of quite a few techniques through the improvement process.No different e-book bargains an analogous point of therapy in this the most important subject in smooth drug improvement.
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Extra info for Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in Medicinal Chemistry) - 2nd Edition
