Download E-books Protein-ligand Interactions: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) PDF

By Hans-Joachim Bohm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

The lock-and-key precept formulated by way of Emil Fischer as early because the finish of the nineteenth century has nonetheless now not misplaced any of its value for the existence sciences. the fundamental elements of ligand-protein interplay might be summarized below the time period 'molecular acceptance' and situation the specificity in addition to balance of ligand binding. Molecular popularity is therefore a valuable subject within the improvement of lively elements, on account that balance and specificity be sure even if a substance can be utilized as a drug. these days, computer-aided prediction and clever molecular layout make a wide contribution to the consistent look for, e. g., superior enzyme inhibitors, and new suggestions equivalent to that of pharmacophores are being constructed. An up to date presentation of an perpetually younger subject, this e-book is an fundamental details resource for chemists, biochemists and pharmacologists facing the binding of ligands to proteins.