Building at the good fortune of the former variations, the Textbook of Drug layout and Discovery, 5th Edition, has been completely revised and up-to-date to supply an entire resource of knowledge on all elements of drug layout and discovery for college kids of chemistry, pharmacy, pharmacology, biochemistry, and medication. the data is gifted in an up to date overview shape with an underlying and basic specialize in the tutorial aspects.
Beginning with an creation to drug layout and discovery, the 1st 8 chapters conceal molecular popularity, ligand-based drug layout, and biostructure-based drug layout. The authors additionally talk about drug-like houses and determination making in medicinal chemistry, chemical biology, traditional items in drug discovery, and in vivo imaging in drug discovery.
The center six chapters offer an summary of peptide and protein drug layout, prodrugs in drug layout and improvement, and enzyme inhibitors. The authors additionally battle through receptors (structure, functionality, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, functionality, and drug binding).
The following chapters tackle vital neurotransmitter structures, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The booklet concludes with an exam of missed illnesses, anticancer brokers, tyrosine kinase receptors, and antibiotics.
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