Download E-books The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors) PDF

A finished, state of the art evaluation of our present figuring out of the molecular and structural biology of 5-HT receptors and their capability use for drug discovery. The authors describe the anatomical, mobile, and subcellular distribution of 5-HT receptors and exhibit a strong method of elucidating their physiological function utilizing knockout mice during which the 5-HT receptors have been deleted. additionally they evaluation our knowing of the physiological role(s) of 5-HT receptors established typically on stories played in genetically engineered mice. Highlights comprise discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor sign transduction.

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